[1]高 彬,孫 娜,常文秀.慢性腎臟病患者血鉀異常相關因素分析[J].醫學信息,2019,(22):91-93.[doi:10.3969/j.issn.1006-1959.2019.22.027]
 GAO Bin,SUN Na,CHANG Wen-xiu.Analysis of Related Factors of Serum Potassium Abnormality in Patients with Chronic Kidney Disease[J].Medical Information,2019,(22):91-93.[doi:10.3969/j.issn.1006-1959.2019.22.027]
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慢性腎臟病患者血鉀異常相關因素分析()
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醫學信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期數:
2019年22期
頁碼:
91-93
欄目:
臨床研究
出版日期:
2019-11-15

文章信息/Info

Title:
Analysis of Related Factors of Serum Potassium Abnormality in Patients with Chronic Kidney Disease
文章編號:
1006-1959(2019)22-0091-03
作者:
高 彬孫 娜常文秀
(天津市第一中心醫院腎病科,天津 300072)
Author(s):
GAO BinSUN NaCHANG Wen-xiu
(Department of Nephrology,Tianjin First Central Hospital,Tianjin 300072,China)
關鍵詞:
慢性腎臟病低鉀血癥高鉀血癥腎小球濾過率
Keywords:
Chronic kidney diseaseHypokalemiaHyperkalemiaGlomerular filtration rate
分類號:
R692
DOI:
10.3969/j.issn.1006-1959.2019.22.027
文獻標志碼:
A
摘要:
目的 分析慢性腎臟病患者(CKD)血鉀異常的臨床特點及其影響因素。方法 選取2014年12月~2018年12月我院診治的321例慢性腎臟病患者,記錄患者性別、年齡、是否服用利尿劑、是否合并高血壓、腎小球濾過率(eGFR)、血肌酐(Scr)、尿素氮(BUN)、二氧化碳(CO2)水平,觀察慢性腎臟病患者血清鉀的異常發生率,比較不同CKD分期(CKD1~5期)患者的血鉀水平、不同血鉀水平患者性別、年齡、是否服用利尿劑、是否合并高血壓、eGFR、Scr、BUN、CO2等差異及其與血鉀的相關性。結果 321例CKD患者中血鉀異常36例,血鉀異常發生率為11.21%。其中低鉀血癥19例、血鉀正;颊285例、高鉀血癥17例;CKD1~2期156例,CKD3a期43例,CKD3b期40例,CKD 4~5期82例;CKD早期患者與CKD晚期患者血鉀水平比較,差異有統計學意義(P<0.05);高鉀血癥患者高血壓所占比例、eGFR、BUN、Scr水平高于血鉀正常及低鉀血癥患者,差異有統計學意義(P<0.05);高鉀血癥患者血清CO2、服用利尿劑比例低于血鉀正常及低鉀血癥患者,差異有統計學意義(P<0.05);不同血鉀水平患者年齡、性別比較,差異無統計學意義(P>0.05);Logistic回歸分析顯示,血清鉀水平與是否服用利尿劑、BUN、Scr呈正相關(P<0.05),與血清CO2、eGFR呈負相關(P<0.05)。結論 慢性腎臟病患者血鉀水平隨CKD分期的進展逐期升高,服用利尿劑、BUN和Scr升高,eGFR和CO2水平降低的患者更容易發生高血鉀癥,臨床應加強對患者腎功能指標的監測,有效控制血鉀異常危險因素。
Abstract:
Objective To analyze the clinical features and influencing factors of serum potassium abnormalities in patients with chronic kidney disease (CKD). Methods A total of 321 patients with chronic kidney disease who were treated in our hospital from December 2014 to December 2018 were enrolled. The patient's gender, age, diuretics, hypertension, glomerular filtration rate (eGFR), serum creatinine were recorded (Scr), urea nitrogen (BUN), carbon dioxide (CO2) levels, observe the abnormal incidence of serum potassium in patients with chronic kidney disease, compare the blood potassium levels of patients with different CKD stages (CKD1~5), gender of different blood potassium levels , age, whether taking diuretics, whether combined with hypertension, eGFR, Scr, BUN, CO2 and other differences and their correlation with serum potassium. Results Of the 321 patients with CKD, 36 had abnormal potassium levels, and the incidence of abnormal potassium was 11.21%. There were 19 cases of hypokalemia, 285 cases of normal potassium and 17 cases of hyperkalemia; 156 cases of CKD1~2, 43 cases of CKD3a, 40 cases of CKD3b, 82 cases of CKD 4~5; early stage of CKD Compared with serum potassium levels in patients with advanced CKD, the difference was statistically significant (P<0.05). The proportion of hypertension, eGFR, BUN and Scr in patients with hyperkalemia were higher than those in patients with normal potassium and hypokalemia,the difference was statistically significant (P<0.05). The serum CO2 and diuretic ratio of patients with hyperkalemia were lower than those with normal potassium and hypokalemia, the difference was statistically significant (P<0.05); different potassium levels There was no significant difference in age and gender between the patients (P>0.05). Logistic regression analysis showed that serum potassium levels were positively correlated with diuretics, BUN and Scr (P<0.05), and negatively correlated with serum CO2 and eGFR(P<0.05).Conclusion The serum potassium level of patients with chronic kidney disease increases with the progression of CKD stage. The patients taking diuretics, BUN and Scr are elevated, and patients with decreased eGFR and CO2 levels are more likely to have hyperkalemia. The clinical function of patients should be strengthened. The monitoring of indicators effectively controls the risk factors of abnormal blood potassium.

參考文獻/References:

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