[1]崔方強.足細胞上皮間質轉分化研究[J].醫學信息,2019,(22):21-23.[doi:10.3969/j.issn.1006-1959.2019.22.008]
 CUI Fang-qiang.Epithelial Transdifferentiation of Podocytes[J].Medical Information,2019,(22):21-23.[doi:10.3969/j.issn.1006-1959.2019.22.008]
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足細胞上皮間質轉分化研究()
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醫學信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期數:
2019年22期
頁碼:
21-23
欄目:
綜述
出版日期:
2019-11-15

文章信息/Info

Title:
Epithelial Transdifferentiation of Podocytes
文章編號:
1006-1959(2019)22-0021-03
作者:
崔方強
(首都醫科大學附屬北京中醫醫院腎病科,北京 100010)
Author(s):
CUI Fang-qiang
(Department of Nephrology,Beijing Traditional Chinese Medicine Hospital,Capital Medical University,Beijing 100010,China)
關鍵詞:
足細胞上皮間質轉分化信號通路慢性腎臟病
Keywords:
PodocytesEpithelial-mesenchymal transitionSignaling pathwayChronic kidney disease
分類號:
R692
DOI:
10.3969/j.issn.1006-1959.2019.22.008
文獻標志碼:
A
摘要:
足細胞是腎小球濾過膜的重要組成部分,在維持腎小球正常濾過功能方面起著至關重要的作用。足細胞上皮間質轉分化(EMT)是多種慢性腎臟疾病蛋白尿產生及疾病進展的重要病理機制。減輕足細胞EMT已經成為慢性腎臟疾病防治研究的熱點;诖,本文主要就足細胞的生理特點、EMT病理過程及相關信號通路作一綜述。
Abstract:
Podocytes are an important component of glomerular filtration membrane and play a vital role in maintaining normal glomerular filtration function. Epithelial mesenchymal transition (EMT) of podocytes is an important pathological mechanism for proteinuria production and disease progression in a variety of chronic kidney diseases. Reducing podocyte EMT has become a hot spot in the prevention and treatment of chronic kidney disease. Based on this, this paper reviews the physiological characteristics of podocytes, pathological processes of EMT and related signaling pathways.

參考文獻/References:

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更新日期/Last Update: 2019-11-15
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