[1]黃慶松,馬愛玲,張 瑞,等.合并微出血對腦小血管閉塞性卒中患者認知功能的影響及其與P300的關系[J].醫學信息,2019,(22):66-68,78.[doi:10.3969/j.issn.1006-1959.2019.22.021]
 HUANG Qing-song,MA Ai-ling,ZHANG Rui,et al.Effect of Combined Microbleeds on Cognitive Function in Patients with Cerebral Small Vessel Occlusive Stroke and Its Relationship with P300[J].Medical Information,2019,(22):66-68,78.[doi:10.3969/j.issn.1006-1959.2019.22.021]
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合并微出血對腦小血管閉塞性卒中患者認知功能的影響及其與P300的關系()
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醫學信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期數:
2019年22期
頁碼:
66-68,78
欄目:
論著
出版日期:
2019-11-15

文章信息/Info

Title:
Effect of Combined Microbleeds on Cognitive Function in Patients with Cerebral Small Vessel Occlusive Stroke and Its Relationship with P300
文章編號:
1006-1959(2019)22-0066-04
作者:
黃慶松馬愛玲張 瑞萬浩鵬李化強
(上海市嘉定區中醫醫院腦病科,上海 201800)
Author(s):
HUANG Qing-songMA Ai-lingZHANG RuiWAN Hao-pengLI Hua-qiang
(Department of Encephalopathy,Jiading District Traditional Chinese Medicine Hospital,Shanghai 201800,China)
關鍵詞:
小血管閉塞性卒中腦微出血認知功能P300
Keywords:
Small vessel occlusive strokeCerebral microbleedsCognitive functionP300
分類號:
R743.3
DOI:
10.3969/j.issn.1006-1959.2019.22.021
文獻標志碼:
A
摘要:
目的 探討合并微出血(CMBs)對腦小動脈閉塞性卒中(SAO)患者認知功能的影響及與事件相關電位(ERP)P300的相關性。方法 選取本院2017年12月~2019年4月腦病科SAO患者70例作為研究對象,應用蒙特利爾認知評估量表(MoCA)進行認知功能評估。應用1.5T超導磁共振對所有患者進行常規序列及磁敏感(SWI)序列檢查,分析SAO患者認知功能損傷與CMBs的關系。采用Keypoint誘發電位儀檢測P300電位,分析SAO患者CMBs與P300電位關系。結果 本研究最終納入70例SAO患者,其中MoCA總分異常者48例,MoCA總分正常者22 例。年齡、教育年限、高血壓病史、白質疏松程度和CMBs的有無與SAO患者MoCA評分異常有關(P<0.05)。Logistic回歸分析發現,CMBs的有無(OR=5.648,95%CI=1.105~28.869,P=0.038)仍然是MoCA評分異常的獨立危險因素。微出血(CMBs)組 MoCA總分降低,P300潛伏期顯著延長、波幅明顯降低,差異均有統計學意義(P<0.05)。CMBs程度與P300潛伏期相關Pz(r=0.252,P<0.05);Cz(r=0.296,P<0.05)。結論 CMBs與SAO患者認知功能損傷相關,伴CMBs的SAO患者P300電位有明顯改變,P300可作為評估SAO合并CMBs患者的認知功能障礙的客觀指標之一。
Abstract:
Objective To investigate the effects of combined microbleeds (CMBs) on cognitive function in patients with cerebral small artery occlusion stroke (SAO) and its correlation with event-related potential (ERP) P300. Methods 70 patients with SAO in encephalopathy from December 2017 to April 2019 in our hospital were selected as subjects, and the cognitive function assessment was performed using the Montreal Cognitive Assessment Scale (MoCA). Routine sequence and magnetic susceptibility (SWI) sequence examinations were performed in all patients with 1.5T superconducting magnetic resonance to analyze the relationship between cognitive impairment and CMBs in SAO patients. The P300 potential was detected by Keypoint evoked potential meter, and the relationship between CMBs and P300 potential in SAO patients was analyzed.Results The study included 70 patients with SAO, including 48 patients with abnormal MoCA scores and 22 patients with normal MoCA scores. Age, years of education, history of hypertension, degree of white matter loosening, and presence or absence of CMBs were associated with abnormal MoCA scores in SAO patients (P<0.05). Logistic regression analysis found that the presence or absence of CMBs (OR=5.648, 95% CI=1.105~28.869, P=0.038) remained an independent risk factor for abnormal MoCA scores. In the micro-bleeding (CMBs) group, the total score of MoCA decreased, the latency of P300 was significantly prolonged, and the amplitude was significantly decreased,the difference was statistically significant (P<0.05).The degree of CMBs is related to the latency of P300 Pz(r=0.252, P<0.05); Cz (r=0.296, P<0.05).Conclusion CMBs are associated with cognitive impairment in SAO patients, and P300 potential in SAO patients with CMBs is significantly altered. P300 can be used as an objective indicator for assessing cognitive dysfunction in patients with SAO and CMBs.

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