[1]劉書斌,劉云庚,陳財福,等.低劑量mFOLFOX6聯合同步三維適形放療在T3期直腸癌術前治療中的可行性[J].醫學信息,2019,(22):109-111.[doi:10.3969/j.issn.1006-1959.2019.22.035]
 LIU Shu-bin,LIU Yun-geng,CHEN Cai-fu,et al.Feasibility of Low-dose mFOLFOX6 Combined with Synchronous Three-dimensional Conformal Radiotherapy for Preoperative Treatment of Rectal Cancer in Stage T3[J].Medical Information,2019,(22):109-111.[doi:10.3969/j.issn.1006-1959.2019.22.035]
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低劑量mFOLFOX6聯合同步三維適形放療在T3期直腸癌術前治療中的可行性()
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醫學信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期數:
2019年22期
頁碼:
109-111
欄目:
臨床研究
出版日期:
2019-11-15

文章信息/Info

Title:
Feasibility of Low-dose mFOLFOX6 Combined with Synchronous Three-dimensional Conformal Radiotherapy for Preoperative Treatment of Rectal Cancer in Stage T3
文章編號:
1006-1959(2019)22-0109-03
作者:
劉書斌1劉云庚2陳財福1易建中2賴景春1
(江西省贛州市人民醫院腫瘤科1,胃腸外科2,江西 贛州 341000)
Author(s):
LIU Shu-bin1LIU Yun-geng2CHEN Cai-fu1YI Jian-zhong2LAI Jing-chun1
(Department of Oncology1,Department of Gastrointestinal Surgery2,People's Hospital of Ganzhou City,Ganzhou 341000,Jiangxi,China)
關鍵詞:
低劑量mFPLFOX6三維適形放療T3期直腸癌
Keywords:
Low dosemFPLFOX6Three-dimensional conformal radiotherapyT3 rectal cancer
分類號:
R735.3+7
DOI:
10.3969/j.issn.1006-1959.2019.22.035
文獻標志碼:
A
摘要:
目的 探討低劑量mFPLFOX6聯合同步三維適形放療治療在T3期直腸癌術前治療中的可行性。方法 選取2016年1月~2018年10月我院收治的T3期中低位直腸癌患者80例,均予以低劑量mFPLFOX6方案同步三維適形放療治療,在治療結束8周后行全直腸系膜切除術,分析患者放化療期間毒性反應發生情況、圍術期并發癥以及手術情況,并評估患者化療后T、N降期情況。結果 所有患者均未出現3級、4級血液學毒性,僅有2例出現放射性皮炎和1例腹瀉的3級非血液學毒性,發生率分別為2.50%和1.25%。治療后,有24例患者T、N同時降期,降期率為30.00%;有49例患者T分期下降,降期率為61.25%;有43例患者N分期下降,降期率為53.75%。圍術期并發癥發生率為7.50%;保肛率為81.25%、遠處轉移率為3.75%。結論 術前低劑量mFPLFOX6聯合同步三維適形放療能夠減少毒性反應發生,有助于T3期直腸癌患者T、N降期,提高保肛率,安全可靠。
Abstract:
Objective To investigate the feasibility of low-dose mFPLFOX6 combined with three-dimensional conformal radiotherapy in the preoperative treatment of rectal cancer in stage T3. Methods 80 patients with moderate to low rectal cancer of T3 who were admitted to our hospital from January 2016 to October 2018 were enrolled in this study. All patients were treated with low-dose mFPLFOX6 synchronous three-dimensional conformal radiotherapy. Total mesorectal excision was performed 8 weeks after the end of treatment. The incidence of toxicity, perioperative complications and surgery during radiotherapy and chemotherapy, and assess the T and N decline after chemotherapy. Results There were no grade 3 or 4 hematologic toxicity in all patients, only 2 cases of radiation dermatitis and 1 case of diarrhea with grade 3 non-hematologic toxicity, with incidence rates of 2.50% and 1.25%, respectively. After treatment, 24 patients with T and N decreased at the same time, the rate of decline was 30.00%; 49 patients with T stage decreased, the rate of decline was 61.25%; 43 patients with N stage decreased, the rate of decline was 53.75% . The perioperative complication rate was 7.50%; the anal sphincter rate was 81.25%, and the distant metastasis rate was 3.75%. Conclusion Preoperative low-dose mFPLFOX6 combined with synchronous three-dimensional conformal radiotherapy can reduce the occurrence of toxicity, help T and N in patients with T3 rectal cancer, and improve the rate of anal sphincm. It is safe and reliable.

參考文獻/References:

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更新日期/Last Update: 2019-11-15
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