[1]伊學軍,翟建新.胱抑素C檢測及其在腎臟相關疾病中的應用[J].醫學信息,2020,(04):55-58.[doi:10.3969/j.issn.1006-1959.2020.04.017]
 YI Xue-jun,ZHAI Jian-xin.Cystatin C Detection and its Application in Kidney-related Diseases[J].Medical Information,2020,(04):55-58.[doi:10.3969/j.issn.1006-1959.2020.04.017]
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胱抑素C檢測及其在腎臟相關疾病中的應用()
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醫學信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期數:
2020年04期
頁碼:
55-58
欄目:
綜述
出版日期:
2020-02-15

文章信息/Info

Title:
Cystatin C Detection and its Application in Kidney-related Diseases
文章編號:
1006-1959(2020)04-0055-04
作者:
伊學軍翟建新
(天津中醫藥大學第一附屬醫院檢驗科,天津 300193)
Author(s):
YI Xue-junZHAI Jian-xin
(Department of Laboratory Medicine,the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China)
關鍵詞:
胱抑素C腎小球濾過率腎病腎損傷
Keywords:
Cystatin CGlomerular filtration rateKidney diseaseKidney injury
分類號:
R446.11
DOI:
10.3969/j.issn.1006-1959.2020.04.017
文獻標志碼:
A
摘要:
胱抑素C屬于半胱氨酸蛋白酶抑制劑家族,是廣泛存在于植物、細菌、病毒、原生動物和哺乳動物組織中的一類重要的蛋白酶,是評定腎小球濾過率(GFR)變化的內源性標志物。其生物學變異小,不受生理因素影響,因此靈敏度、特異性均優于GFR其他內源性標志物。大量研究表明胱抑素C與急性腎衰竭、糖尿病腎病、肝臟并發腎病等腎相關性疾病的發生密切相關。本文通過對胱抑素C的生物學特性和功能、檢測方法及其作一綜述,以期為臨床檢驗提供參考。
Abstract:
Cystatin C belongs to the family of cysteine protease inhibitors. It is an important protease widely found in plant, bacterial, viral, protozoan and mammalian tissues. It is an endogenous marker to assess changes in glomerular filtration rate (GFR). Because its biological variation is small and is not affected by physiological factors, its sensitivity and specificity are better than other endogenous markers of GFR. Many studies have shown that cystatin C is closely related to the occurrence of kidney-related diseases such as acute renal failure, diabetic nephropathy, and liver-complicated nephropathy.This article reviews the biological characteristics and functions of cystatin C, its detection methods, and its application in kidney lesions and other diseases involving kidneys, in order to provide a reference for clinical tests.

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