[1]楊玥欣,汪 志,楊 欣,等.食管癌放療的劑量學和臨床療效研究[J].醫學信息,2020,(04):72-76.[doi:10.3969/j.issn.1006-1959.2020.04.022]
 YANG Yue-xin,WANG Zhi,YANG Xin,et al.Dosimetry and Clinical Efficacy of Radiotherapy for Esophageal Cancer[J].Medical Information,2020,(04):72-76.[doi:10.3969/j.issn.1006-1959.2020.04.022]
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食管癌放療的劑量學和臨床療效研究()
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醫學信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期數:
2020年04期
頁碼:
72-76
欄目:
論著
出版日期:
2020-02-15

文章信息/Info

Title:
Dosimetry and Clinical Efficacy of Radiotherapy for Esophageal Cancer
文章編號:
1006-1959(2020)04-0072-05
作者:
楊玥欣汪 志楊 欣
(1.安徽醫科大學第一附屬醫院放療科,安徽 合肥 230032;2.蚌埠醫學院第一附屬醫院放療科,安徽 蚌埠 233004)
Author(s):
YANG Yue-xinWANG ZhiYANG Xinet al
(1.Department of Radiotherapy,the First Affiliated Hospital of Anhui Medical University,Hefei 230032,Anhui,China;2.Department of Radiotherapy,the First Affiliated Hospital of Bengbu Medical College,Bengbu 233004,Anhui,China)
關鍵詞:
食管癌容積調強放療靜態調強放療劑量學
Keywords:
Esophageal cancerVolumetric modulated arc radiotherapyStatic intensity-modulated radiotherapyDosimetry
分類號:
R735.1
DOI:
10.3969/j.issn.1006-1959.2020.04.022
文獻標志碼:
A
摘要:
目的 比較食管癌放療中容積旋轉調強放療(RapidArc)和靜態調強放療(sIMRT)的劑量學、毒副反應發生率和治療反應率差異。方法 收集2018年11月~2019年8月安徽醫科大學第一附屬醫院68例經病理診斷為食管鱗癌的患者資料,按照不同放療方法分為RapidArc組(20例),sIMRT組(48例)。比較兩組靶區的適形性指數(CI)、均勻性指數(HI)和機器跳數(MU)、危及器官受量、毒副反應發生率和治療反應率。結果 RapidArc組CI高于sIMRT組(0.79±0.06 vs 0.72±0.10),且MU小于sIMRT組[(445.52±65.63)MU vs (554.62±106.08)MU](P<0.05),兩組HI比較,差異無統計學意義(P>0.05)。RapidArc組胸上段食管癌的雙肺V30、心臟V30、V40、Dmean、脊髓D2均小于sIMRT組(P<0.05);胸中段的心臟V30、V40、Dmean,脊髓V20小于sIMRT組(P<0.05);胸下段的脊髓V5、V20上小于sIMRT組(P<0.05)。兩組毒副反應發生率和治療反應率比較,差異無統計學意義(P>0.05)。結論 RapidArc能顯著提高靶區適形度,并降低肺高劑量區、心臟和脊髓受量,但其劑量學優勢能否轉化為臨床獲益仍待進一步考證。
Abstract:
Objective To compare the dosimetry, incidence of toxic and side effects, and treatment response rates of volumetric modulated arc radiotherapy (RapidArc) and static intensity modulated radiotherapy (sIMRT) in esophageal cancer radiotherapy. Methods From November 2018 to August 2019, 68 patients with pathologically diagnosed esophageal squamous cell carcinoma were collected from the First Affiliated Hospital of Anhui Medical University.According to different radiotherapy methods, they were divided into RapidArc group (20 cases) and sIMRT group (48 cases).The conformation index(CI),homogeneity index (HI),monitor units (MU),the dose to organs at risk, the incidence of toxic and side effects, and the response rate of treatment were compared between the two groups. Results The CI of the RapidArc group was higher than that of the sIMRT group (0.79±0.06 vs 0.72±0.10), and the MU was smaller than that of the sIMRT group [(445.52±65.63) MU vs (554.62±106.08) MU](P<0.05).There was no significant difference in HI between the two groups (P>0.05). The lungs V30, heart V30, V40, Dmean, and spinal cord D2 of the upper thoracic esophageal cancer in the RapidArc group were all smaller than those in the sIMRT group(P<0.05). The heart V30, V40, Dmean, and spinal cord V20 in the middle of the chest were less than sIMRT group(P<0.05); the lower spinal cord V5 and V20 were smaller than the sIMRT group(P <0.05). There was no significant difference in the incidence of side effects and treatment response between the two groups (P>0.05). Conclusion RapidArc can significantly increase the conformity of the target area and reduce the volume of high-dose lung, heart and spinal cord. However, whether its dosimetric advantages can be translated into clinical benefits remains to be further investigated.

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更新日期/Last Update: 2020-02-15
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