[1]曹自平,江豁達,姜良勇,等.乳腺癌Dab1、E-cad的表達及其在上皮間質轉化中的作用[J].醫學信息,2020,(04):80-82.[doi:10.3969/j.issn.1006-1959.2020.04.024]
 CAO Zi-ping,JIANG Huo-da,JIANG Liang-yong,et al.Expression of Dab1,E-cad in Breast Cancer and Its Role in Epithelial-mesenchymal Transition[J].Medical Information,2020,(04):80-82.[doi:10.3969/j.issn.1006-1959.2020.04.024]
點擊復制

乳腺癌Dab1、E-cad的表達及其在上皮間質轉化中的作用()
分享到:

醫學信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期數:
2020年04期
頁碼:
80-82
欄目:
論著
出版日期:
2020-02-15

文章信息/Info

Title:
Expression of Dab1,E-cad in Breast Cancer and Its Role in Epithelial-mesenchymal Transition
文章編號:
1006-1959(2020)04-0080-03
作者:
曹自平江豁達姜良勇
(1.佳木斯大學,黑龍江 佳木斯 154007;2.佳木斯大學附屬第一醫院腫瘤外科,黑龍江 佳木斯 154003)
Author(s):
CAO Zi-pingJIANG Huo-daJIANG Liang-yonget al
(1.Jiamusi University,Jiamusi 154007,Heilongjiang,China;2.Department of Oncology,the First Affiliated Hospital of Jiamusi University,Jiamusi 154003,Heilongjiang,China)
關鍵詞:
殘障蛋白-1E-鈣粘蛋白上皮間質轉化乳腺癌免疫組織化學
Keywords:
Disability protein-1E-cadherinEpithelial-mesenchymal transitionBreast cancerImmunohistochemistry
分類號:
R737.31
DOI:
10.3969/j.issn.1006-1959.2020.04.024
文獻標志碼:
A
摘要:
目的 探討乳腺癌殘障蛋白-1(Dab1)與E-鈣粘蛋白(E-cad)在乳腺癌中的表達及其與上皮間質轉化(EMT)的相關性。方法 收集2018年3月~2019年3月佳木斯大學附屬第一醫院病理科乳腺癌組織與癌旁組織各80例,采用免疫組織化學方法檢測乳腺癌Dab1和E-cad的表達,并分析其與患者臨床病理特征的關系。結果 Dab1在乳腺癌組織中的陽性表達率為45.00%(36/80),在癌旁組織中的陽性表達率為75.00%(60/80);E-cad在乳腺癌組織中的陽性表達率為60.00%(48/80),在癌旁組織中的陽性表達為85.00%(68/80),差異均有統計學意義(P<0.05);不同年齡、月經史、腫瘤大小間Dab1、E-cad陽性率比較,差異無統計學意義(P>0.05);不同TNM分期、分化程度及淋巴結轉移情況間Dab1、E-cad陽性率比較,差異有統計學意義(P<0.05);Spearman相關分析顯示,Dab1和E-cad呈正相關(r=0.226,P<0.05)。結論 Dab1、E-cad在乳腺癌中異常表達,二者呈正相關,均與乳腺癌臨床分期、腫瘤分化程度、淋巴結轉移相關,可作為判斷乳腺癌預后的指標。
Abstract:
Objective To investigate the expression of breast cancer disability protein-1(Dab1) and E-cadherin(E-cad)in breast cancer and their correlation with epithelial-mesenchymal transition (EMT).Methods From March 2018 to March 2019, 80 cases of breast cancer tissues and adjacent tissues from the Department of Pathology of the First Affiliated Hospital of Jiamusi University were selected.The expressions of Dab1 and E-cad in breast cancer were detected by immunohistochemistry,and their correlation with the relationship between the clinicopathological characteristics of patients.Results The positive expression rate of Dab1 in breast cancer tissues was 45.00% (36/80),and the positive expression rate in adjacent tissues was 75.00%(60/80).The positive expression rate of E-cad in breast cancer tissues 60.00%(48/80),the positive expression in the adjacent tissues was 85.00%(68/80),the differences were statistically significant(P<0.05);There was no significant difference in Dab1, E-cad positive rates between different ages,menstrual history,and tumor size(P>0.05);Dab1,E-cad positive rates were different among different TNM stages,degrees of differentiation, and lymph node metastasis,the difference was statistically significant(P<0.05);Spearman correlation analysis showed that Dab1 and E-cad were positively correlated (r=0.226,P<0.05).Conclusion Dab1 and E-cad are abnormally expressed in breast cancer.Both of them are positively correlated,and both are related to the clinical stage of breast cancer,the degree of tumor differentiation,and lymph node metastasis.Therefore,the two can be used as indicators to judge the prognosis of breast cancer.

參考文獻/References:

[1]Dasgupta P,Aitken JF,Pyke C,et al.Competing mortality risks among women aged 50-79 years when diagnosed with invasive breast cancer,Queensland,1997-2012[J].Breast,2018(41):113-119. [2]Wei Z,Shan Z,Shaikh ZA.Epithelial-mesenchymal transition in breast epithelial cells treated with cadmium and the role of Snail[J].Toxicology and Applied Pharmacology,2018,344(1):46-55. [3]劉志嫻,魏爾清,盧韻碧.上皮—間質轉化在腫瘤發生發展中的作用研究進展[J].浙江大學學報(醫學版),2015,44(2):211-216. [4]郭魚波,王春暉,裴曉華.乳腺癌細胞上皮間質轉化的分子機制及其防治的研究進展[J].中國腫瘤,2018,27(12):933-943. [5]雷珍,鐘錫明,周岐,等.p53,Ki-67及E-鈣粘蛋白在三陰性乳腺癌中的表達及預后[J].臨床與病理雜志,2017(2):308-314. [6]da Cunha IW,Souza MJ,da Costa WH,et al.Epithelial-mesenchymal transition(EMT)phenotype at invasion front of squamous cell carcinoma of the penis influences oncological outcomes[J].Urol Oncol,2016,34(433):e19-e26. [7]Ortega FG,Alvarez-Cubero MJ,Nadal R,et al.EMT and EGFR in CTCs cytokeratin negative non-metastatic breast cancer[J].Oncotarget,2014,5(17):7486-7497. [8]張建華.DCC介導的Dab1磷酸化參與調控新皮質神經元輻射遷移的研究[D].東北師范大學,2018. [9]王瓊.Reelin-dab1信號轉導通路在鋁致Aβ代謝異常中的作用及其機制研究[D].山西醫科大學,2018,31(8):3278-3281. [10]王同玫,張一奇,文普帥,等.乳腺癌組織中Dab1蛋白表達及其臨床相關性研究[J].中國現代醫學雜志,2018,28(15):32-36.

更新日期/Last Update: 2020-02-15
中国足彩网竞彩 广博股份股票 临沂外盘期货配资 北京11选5预测推荐 股票配资平台代理商协议 辽宁十一选五真正 15选5今晚专家预测推荐 黑龙江11选五前三组 北京快中彩和值走势 河北十一选五遗漏一定牛 黑龙江11选5手机版