[1]闕祿輝.閉合性骨折后下肢DVT患者D-二聚體、纖維蛋白原與Caprini評分的相關性分析[J].醫學信息,2020,(04):101-103.[doi:10.3969/j.issn.1006-1959.2020.04.030]
 QUE Lu-hui.Correlation Analysis of D-Dimer,Fibrinogen and Caprini Score in Patients with Lower Extremity DVT After Closed Fracture[J].Medical Information,2020,(04):101-103.[doi:10.3969/j.issn.1006-1959.2020.04.030]
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閉合性骨折后下肢DVT患者D-二聚體、纖維蛋白原與Caprini評分的相關性分析()
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醫學信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期數:
2020年04期
頁碼:
101-103
欄目:
論著
出版日期:
2020-02-15

文章信息/Info

Title:
Correlation Analysis of D-Dimer,Fibrinogen and Caprini Score in Patients with Lower Extremity DVT After Closed Fracture
文章編號:
1006-1959(2020)04-0101-03
作者:
闕祿輝
(上饒市廣信區人民醫院檢驗科,江西 上饒 334100)
Author(s):
QUE Lu-hui
(Department of Laboratory Medicine,People’s Hospital of Guangxin District,Shangrao 334100,Jiangxi,China)
關鍵詞:
閉合性骨折下肢深靜脈血栓D-二聚體纖維蛋白原Caprini評分
Keywords:
Closed fractureLower extremityDeep vein thrombosisD-dimerFibrinogenCaprini score
分類號:
R683
DOI:
10.3969/j.issn.1006-1959.2020.04.030
文獻標志碼:
A
摘要:
目的 分析閉合性骨折后下肢深靜脈血栓(DVT)患者D-二聚體、纖維蛋白原與Caprini評分的相關性。方法 選擇2017年1月~2019年10月我院收治的136例閉合性骨折患者作為研究對象,根據是否并發下肢DVT進行分組,其中42例閉合性骨折后發生下肢DVT患者作為觀察組,94例骨折后未發生下肢DVT患者作為對照組,比較兩組血漿D-二聚體、纖維蛋白原水平及Caprini評分,采用多因素Logistic回歸分析及Pearson相關性分析D-二聚體、纖維蛋白原與Caprini評分的相關性,采用受試者工作特征(ROC)曲線評價D-二聚體、纖維蛋白原聯合Caprini評分對閉合性骨折后下肢DVT的預測效能。結果 觀察組血漿D-二聚體、纖維蛋白原水平及Caprini評分均高于對照組,差異有統計學意義(P<0.05);多因素Logistic回歸分析顯示,D-二聚體、纖維蛋白原水平及Caprini評分均是閉合性骨折后下肢DVT的獨立影響因素(P<0.05);Pearson相關性分析顯示,閉合性骨折后下肢DVT患者血漿D-二聚體、纖維蛋白原水平均與Caprini評分呈正相關(r=0.542、0.631,P<0.05);ROC曲線分析顯示,D-二聚體、纖維蛋白原聯合Caprini評分預測閉合性骨折后下肢DVT的ROC曲線下面積(AUC)為0.915,高于D-二聚體的0.710、纖維蛋白原的0.640和Caprini評分的0.680,差異有統計學意義(Z=4.812、5.621、6.127,P<0.05)。結論 閉合性骨折后下肢DVT患者D-二聚體、纖維蛋白原與Caprini評分的關系密切,三者聯合預測下肢DVT的效能較好。
Abstract:
Objective To analyze the correlation between D-dimer, fibrinogen and Caprini score in patients with lower extremity deep vein thrombosis (DVT) after closed fracture. Methods A total of 136 patients with closed fractures admitted to our hospital from January 2017 to October 2019 were selected as the research subjects. They were grouped according to whether they had concurrent lower limb DVT. Among them, 42 patients with lower limb DVT after closed fracture were used as the observation group and 94 fractures were observed. Patients who did not develop lower extremity DVT were used as a control group. Plasma D-dimer, fibrinogen levels and Caprini scores were compared between the two groups. Multivariate Logistic regression analysis and Pearson correlation analysis were used to analyze D-dimer, fibrinogen and Caprini correlation of the scores, using the receiver operating characteristic (ROC) curve to evaluate the predictive power of D-dimer, fibrinogen, and Caprini scores for lower limb DVT after closed fractures.Results The levels of D-dimer, fibrinogen and Caprini scores in the observation group were higher than those in the control group,the differences were statistically significant (P<0.05). Multivariate Logistic regression analysis showed that D-dimer, fibrinogen level, and Caprini score were independent factors affecting lower limb DVT after closed fracture(P<0.05); Pearson correlation analysis showed that lower limb DVT after closed fracture Patients’ plasma D-dimer and fibrinogen levels were positively correlated with Caprini scores(r=0.542,0.631,P<0.05);ROC curve analysis showed that D-dimer and fibrinogen combined with Caprini scores predict closed fractures The area under the ROC curve (AUC) of hindlimb DVT was 0.915, which was higher than 0.710 for D-dimer, 0.640 for fibrinogen, and 0.680 for Caprini score,the differences were statistically significant (Z=4.812,5.621,6.127,P<0.05).Conclusion D-dimer, fibrinogen, and Caprini score are closely related in patients with DVT of lower extremity after closed fracture. The combination of the three predicts the effectiveness of DVT in lower extremity.

參考文獻/References:

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