[1]白巧紅.未分化結締組織病的臨床特點分析[J].醫學信息,2020,(04):109-111.[doi:10.3969/j.issn.1006-1959.2020.04.033]
 BAI Qiao-hong.Analysis of Clinical Characteristics of Undifferentiated Connective Tissue Disease[J].Medical Information,2020,(04):109-111.[doi:10.3969/j.issn.1006-1959.2020.04.033]
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未分化結締組織病的臨床特點分析()
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醫學信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期數:
2020年04期
頁碼:
109-111
欄目:
臨床研究
出版日期:
2020-02-15

文章信息/Info

Title:
Analysis of Clinical Characteristics of Undifferentiated Connective Tissue Disease
文章編號:
1006-1959(2020)04-0109-03
作者:
白巧紅
(運城市中心醫院風濕免疫科,山西 運城 044000)
Author(s):
BAI Qiao-hong
(Department of Rheumatology and Immunology,Yuncheng Central Hospital,Yuncheng 044000,Shanxi,China)
關鍵詞:
未分化結締組織病臨床特點轉歸情況
Keywords:
ndifferentiated connective tissue diseaseClinical characteristicsOutcome
分類號:
R593.2
DOI:
10.3969/j.issn.1006-1959.2020.04.033
文獻標志碼:
A
摘要:
目的 了解未分化結締組織。║CTD)的臨床特點及發展規律。方法 收集2015年1月~2019年1月運城市中心醫院住院的128例UCTD患者臨床資料,分析其一般臨床癥狀、實驗室檢查結果、影像學表現及隨訪結果與轉歸情況。結果 128例UCTD患者,臨床表現以關節癥狀為主,其次為雷諾現象、皮膚病變、口干眼干、發熱、漿膜腔積液、口腔潰瘍、肺纖維化。實驗室指標中35例(27.34%)抗RNP抗體陽性,24例(18.75%)抗SSA抗體陽性,2例(1.56%)抗PM/SSC抗體陽性,11例(8.59%)RF陽性,其余抗體均為陰性;補體C3下降4例(3.13%),補體C4下降3例(2.34%),免疫球蛋白G增高21例(16.41%)。影像學檢查中腹部彩超見肝脾、淋巴結腫大8例(6.25%),心臟彩超見心包積液2例(1.56%),肺部CT見胸腔積液7例(5.47%),肺纖維化2例(1.56%)。隨訪中2例失訪,1例誤診,4例完全緩解,67例仍為UCTD(53.60%),54例發展為CTD(43.20%),其中17例分化為SLE,13例分化為SSC,11例分化為PSS,7例分化為PM/DM,5例分化為MCTD,1例分化為為RA。SLE、SSC、PSS、PM/DM患者不同臨床癥狀占比比較,差異有統計學意義(P<0.05);MCTD患者不同臨床癥狀占比比較,差異無統計學意義(P>0.05)。結論 UCTD臨床表現多樣,少部分可能完全緩解,一部分可能持續未分化狀態,一部分患者可進展為SLE、SSC、PSS、PM/DM、MCTD、RA。因此,了解UCTD的臨床特點及轉歸情況對于改善患者預后至關重要。
Abstract:
Objective To understand the clinical characteristics and development rules of undifferentiated connective tissue disease (UCTD).Methods The clinical data of 128 UCTD patients admitted from January 2015 to January 2019 in Yuncheng Central Hospital were analyzed, and their general clinical symptoms, laboratory test results, imaging findings, and follow-up results and outcomes were analyzed.Results The clinical manifestations of 128 UCTD patients were mainly joint symptoms, followed by Raynaud’s phenomenon, skin lesions, dry mouth and dry eyes, fever, serous fluid, oral ulcers, and pulmonary fibrosis. Among the laboratory indicators, 35 cases (27.34%) were positive for anti-RNP antibodies, 24 cases (18.75%) were positive for anti-SSA antibodies, 2 cases (1.56%) were positive for anti-PM/SSC antibodies, 11 cases (8.59%) were positive for RF, and the remaining antibodies all were negative; complement C3 decreased in 4 cases (3.13%), complement C4 decreased in 3 cases (2.34%), and immunoglobulin G increased in 21 cases (16.41%). In the imaging examination, 8 cases (6.25%) of liver and spleen and lymph nodes were seen by color Doppler ultrasound of the abdomen, 2 cases (1.56%) of pericardial effusion of the sonography of the heart,CT of the lung showed pleural effusion in 7 cases (5.47%) and pulmonary fibrosis in 2 cases (1.56%). During follow-up, 2 cases were lost to follow-up, 1 case was misdiagnosed, 4 cases were completely resolved, 67 cases were still UCTD (53.60%), 54 cases developed CTD (43.20%), 17 of them were differentiated into SLE, 13 were into SSC, 11 cases was differentiated into PSS, 7 case was differentiated into PM/DM, 5 case was differentiated into MCTD, and 1 case was differentiated into RA. The proportion of different clinical symptoms in patients with SLE, SSC, PSS, PM/DM was statistically significant (P<0.05); the proportion of different clinical symptoms in MCTD patients was not statistically significant (P>0.05).Conclusion The clinical manifestations of UCTD are diverse. A small part may completely resolve, some may continue to be undifferentiated, and some patients may progress to SLE, SSC, PSS, PM/DM, MCTD, RA. Therefore, understanding the clinical characteristics and outcomes of UCTD is important to improve the prognosis of patients.

參考文獻/References:

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更新日期/Last Update: 2020-02-15
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