[1]蔡 玲.不同胰島素給藥模式對高齡妊娠期糖尿病患者血糖控制及母嬰結局的影響[J].醫學信息,2020,(04):141-143.[doi:10.3969/j.issn.1006-1959.2020.04.045]
 CAI Ling.Effects of Different Insulin Administration Modes on Blood Glucose Control andMaternal and nfant Outcomes in Elderly Gestational Diabetes Mellitus Patients[J].Medical Information,2020,(04):141-143.[doi:10.3969/j.issn.1006-1959.2020.04.045]
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不同胰島素給藥模式對高齡妊娠期糖尿病患者血糖控制及母嬰結局的影響()
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醫學信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期數:
2020年04期
頁碼:
141-143
欄目:
藥物與臨床
出版日期:
2020-02-15

文章信息/Info

Title:
Effects of Different Insulin Administration Modes on Blood Glucose Control andMaternal and nfant Outcomes in Elderly Gestational Diabetes Mellitus Patients
文章編號:
1006-1959(2020)04-0141-03
作者:
蔡 玲
(襄州區人民醫院產科,湖北 襄陽 441000)
Author(s):
CAI Ling
(Department of Obstetrics,Xiangzhou District People’s Hospital,Xiangyang 441000,Hubei,China)
關鍵詞:
胰島素多次皮下給藥胰島素泵妊娠期糖尿病血糖母嬰結局
Keywords:
InsulinMultiple subcutaneous administrationInsulin pumpGestational diabetes mellitusBlood glucoseMaternal and infant outcomes
分類號:
R714.25
DOI:
10.3969/j.issn.1006-1959.2020.04.045
文獻標志碼:
A
摘要:
目的 比較胰島素泵持續皮下注射與多次皮下注射兩種胰島素給藥模式對高齡妊娠期糖尿。℅DM)患者血糖控制及母嬰結局的影響。方法 選取2017年1月~2018年6月襄州區人民醫院收治的高齡GDM患者100例作為研究對象,按照隨機數字表法分為對照組和觀察組,每組50例。兩組均予以胰島素治療,對照組采用多次皮下注射的給藥模式,觀察組采用胰島素泵持續皮下注射的給藥模式,比較兩組血糖控制情況[空腹血糖(FPG)、餐后 2h 血糖(2h PG)、糖化血紅蛋白(HbA1c)]、治療前后血清同型半胱氨酸(Hcy)及胱抑素C(Cys-C)水平變化及母嬰結局。結果 觀察組血糖達標時間短于對照組,胰島素用量少于對照組,差異有統計學意義(P<0.05)。治療后,兩組FPG、2h PG、HbA1c、Hcy、Cys-C低于治療前,且觀察組低于對照組,差異有統計學意義(P<0.05)。觀察組妊娠期高血壓、低血糖、早產、羊水過多及新生兒窒息發生率低于對照組,差異有統計學意義(P<0.05);兩組死胎、巨大兒、胎兒生長受限、畸形發生率比較,差異無統計學意義(P>0.05)。結論 相比于多次皮下注射模式,胰島素泵持續皮下注射的胰島素給藥模式能夠有效提高血糖控制效果,降低血清Hcy、Cys-C水平,改善母嬰結局。
Abstract:
Objective To compare the effects of continuous subcutaneous injection and multiple subcutaneous injections of insulin pump on insulin glucose control and maternal and infant outcomes in elderly patients with gestational diabetes mellitus (GDM).Methods A total of 100 elderly patients with GDM who were treated in Xiangzhou District People’s Hospital from January 2017 to June 2018 were selected as research objects. They were divided into control group and observation group according to the random number table method, with 50 cases in each group. The two groups were treated with insulin. The control group used multiple subcutaneous injections. The observation group used an insulin pump for continuous subcutaneous injections. The two groups were compared for blood glucose control[fasting plasma glucose(FPG),2h postprandial glucose(2h PG),glycosylated hemoglobin(HbA1c)], serum homocysteine (Hcy) and cystatin C (Cys-C) levels and maternal and child outcomes.Results The blood glucose of the observation group was shorter than that of the control group, and the amount of insulin was less than that of the control group,the difference was statistically significant(P<0.05). After treatment, FPG,2h PG, HbA1c, Hcy, and Cys-C were lower in the two groups than before treatment, and the observation group was lower than the control group,the difference was statistically significant (P<0.05).The observation group had lower rates of hypertension, hypoglycemia, preterm birth, polyhydramnios, and neonatal asphyxia in the observation group than the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of stillbirth, gigantic infants, fetal growth restriction, and malformations between the two groups(P>0.05).Conclusion Compared with the multiple subcutaneous injection mode, the continuous subcutaneous injection of insulin pump by the insulin pump can effectively improve blood glucose control, reduce serum Hcy, Cys-C levels, and improve maternal and infant outcomes.

參考文獻/References:

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