[1]花國輝.不同劑量阿托伐他汀治療心梗后無癥狀心衰的療效比較[J].醫學信息,2020,(04):153-154.[doi:10.3969/j.issn.1006-1959.2020.04.050]
 HUA Guo-hui.Comparison of the Effects of Different Doses of Atorvastatin on Asymptomatic Heart Failure After Myocardial Infarction[J].Medical Information,2020,(04):153-154.[doi:10.3969/j.issn.1006-1959.2020.04.050]
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不同劑量阿托伐他汀治療心梗后無癥狀心衰的療效比較()
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醫學信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期數:
2020年04期
頁碼:
153-154
欄目:
藥物與臨床
出版日期:
2020-02-15

文章信息/Info

Title:
Comparison of the Effects of Different Doses of Atorvastatin on Asymptomatic Heart Failure After Myocardial Infarction
文章編號:
1006-1959(2020)04-0153-02
作者:
花國輝
(撫順石化總醫院內科,遼寧 撫順 113000)
Author(s):
HUA Guo-hui
(Department of Internal Medicine,Fushun Petrochemical General Hospital,Fushun 113000,Liaoning,China)
關鍵詞:
不同劑量阿托伐他汀心梗心衰
Keywords:
Different dosesAtorvastatinMyocardial infarctionHeart failure
分類號:
R541.6;R542.2
DOI:
10.3969/j.issn.1006-1959.2020.04.050
文獻標志碼:
A
摘要:
目的 分析不同劑量阿托伐他汀治療心梗后無癥狀心衰的療效。方法 選擇2018年1月~2019年1月在我院診治的120例心梗后無癥狀心衰患者,采用隨機數字表法分為對照組和觀察組,各60例,對照組給予20 mg/d阿托伐他汀治療,觀察組給予40 mg/d阿托伐他汀治療,比較兩組臨床治療總有效率、治療前后心率(HR)、左室射血分數(LVEF)、心室收縮末期容積(LVESV)、血漿BNP、超敏C-反應蛋白(hs-CRP)水平。結果 觀察組治療總有效率為93.33%,高于對照組的81.67%,差異有統計學意義(P<0.05);治療后兩組LVEF均高于治療前,且觀察組高于對照組,差異有統計學意義(P<0.05);治療后兩組HR、LVESV、BNP、hs-CRP均低于治療前,且觀察組低于對照組,差異有統計學意義(P<0.05);兩組均未發生嚴重不良反應。結論 不同劑量阿托伐他汀治療心梗后無癥狀心衰均具有一定的療效,40 mg/d阿托伐他汀治療效果優于 20 mg/d,更有助于改善患者心功能指標,未增加不良反應,值得臨床應用。
Abstract:
Objective To analyze the effect of different doses of atorvastatin on asymptomatic heart failure after myocardial infarction.Methods 120 patients with asymptomatic heart failure after myocardial infarction diagnosed and treated in our hospital from January 2018 to January 2019 were selected and divided into a control group and an observation group by random number table method, 60 cases each, and the control group was given 20 mg/d Atorvastatin treatment. The observation group was given 40 mg/d atorvastatin treatment. The total effective rate, heart rate (HR), left ventricular ejection fraction (LVEF), and end ventricular systolic volume (LVESV) were compared between the two groups.Plasma BNP, high-sensitivity C-reactive protein (hs-CRP) levels.Results The total effective rate of treatment in the observation group was 93.33%, which was higher than 81.67% in the control group,the difference was statistically significant (P<0.05). After treatment, the LVEF of the two groups was higher than before the treatment, and the observation group was higher than the control group,the difference was statistically significant (P<0.05); HR, LVESV, BNP, and hs-CRP were lower in the two groups after treatment than before treatment, and the observation group was lower than the control group,the difference was statistically significant(P<0.05); No serious adverse reactions occurred in the groups.Conclusion Different doses of atorvastatin have a certain effect in the treatment of asymptomatic heart failure after myocardial infarction. The effect of atorvastatin at 40 mg/d is better than 20 mg/d, which is helpful to improve the cardiac function of patients without increasing. Adverse reactions are worthy of clinical application.

參考文獻/References:

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