[1]錢自強,李 青,李志芳,等.血清CA125、HE4及ROMA在卵巢腫瘤良惡性診斷中的應用價值[J].醫學信息,2020,(04):175-176.[doi:10.3969/j.issn.1006-1959.2020.04.059]
 QIAN Zi-qiang,LI Qing,LI Zhi-fang,et al.Application Value of Serum CA125,HE4 and ROMA in the Diagnosis of Benign and Malignant Ovarian Tumors[J].Medical Information,2020,(04):175-176.[doi:10.3969/j.issn.1006-1959.2020.04.059]
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血清CA125、HE4及ROMA在卵巢腫瘤良惡性診斷中的應用價值()
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醫學信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期數:
2020年04期
頁碼:
175-176
欄目:
診療技術
出版日期:
2020-02-15

文章信息/Info

Title:
Application Value of Serum CA125,HE4 and ROMA in the Diagnosis of Benign and Malignant Ovarian Tumors
文章編號:
1006-1959(2020)04-0175-02
作者:
錢自強李 青李志芳
(安徽醫科大學附屬安慶醫院婦產科,安徽 安慶 246000)
Author(s):
QIAN Zi-qiangLI QingLI Zhi-fanget al
(Department of Obstetrics and Gynecology,Anqing Hospital,Anhui Medical University,Anqing 246000,Anhui,China)
關鍵詞:
血清CA125HE4ROMA卵巢腫瘤良惡性
Keywords:
Serum CA125HE4ROMABenign and malignant ovarian tumors
分類號:
R737.31
DOI:
10.3969/j.issn.1006-1959.2020.04.059
文獻標志碼:
A
摘要:
目的 研究血清糖類抗原125(CA125)、人附睪分泌蛋白4(HE4)及卵巢癌風險預測模型(ROMA)對于卵巢腫瘤良惡性診斷中的應用價值。方法 回顧性分析2018年1月~12月我院收治的經手術病理確診的卵巢腫瘤患者124例,其中47例為卵巢癌患者設為卵巢癌組,77例卵巢良性腫瘤患者設為卵巢良性腫瘤組,通過卵巢癌風險預測模型分析軟件計算得出ROMA指數,比較兩組血清CA125、HE4及ROMA指數,分析血清CA125、HE4及ROMA指數對卵巢惡性腫瘤的診斷效能,以卵巢良性腫瘤組為對照繪成受試者工作特征(ROC)曲線并計算曲線下面積(AUC)。結果 卵巢癌組血清CA125、HE4及ROMA指數均高于卵巢良性腫瘤組,差異具有統計學意義(P<0.05),ROMA指數的敏感度高于HE4、特異度高于CA125,且陽性預測值及陰性預測值均優于HE4或CA125單一檢測(P<0.05),血清CA125、HE4和ROMA指數的ROC-AUC分別是0.916、0.869、0.859。結論 ROMA指數相對于血清CA125及HE4,在卵巢腫瘤的良惡性鑒別中臨床應用價值更高。
Abstract:
Objective To study the application value of serum carbohydrate antigen 125 (CA125), human epididymal secretory protein 4 (HE4) and ovarian cancer risk prediction model (ROMA) for the diagnosis of benign and malignant ovarian tumors.Methods A retrospective analysis of 124 patients with ovarian tumors diagnosed by surgery and pathology admitted in our hospital from January to December 2018, of which 47 were ovarian cancer patients were set as ovarian cancer group, 77 benign ovarian tumor patients were set as benign ovarian tumor group The ROMA index was calculated by ovarian cancer risk prediction model analysis software. The serum CA125, HE4 and ROMA indexes were compared between the two groups. The diagnostic efficacy of serum CA125, HE4 and ROMA indexes on ovarian malignant tumors was analyzed. Create a receiver operating characteristic (ROC) curve and calculate the area under the curve (AUC).Results The serum CA125, HE4 and ROMA indexes of ovarian cancer group were higher than those of benign ovarian tumor group, the difference was statistically significant(P<0.05). The sensitivity of ROMA index was higher than HE4, the specificity was higher than CA125, and the positive predictive value and negative The predicted values were better than the single detection of HE4 or CA125(P<0.05).The ROC-AUC of serum CA125, HE4 and ROMA indexes were 0.916, 0.869, and 0.859, respectively. Conclusion Compared with serum CA125 and HE4, ROMA index has higher clinical application value in identifying benign and malignant ovarian tumors.

參考文獻/References:

[1]馮艾,張琳,陳艷炯.不同絕經狀態女性血清HE4、CA125和ROMA指數在卵巢癌診斷中的意義[J].西安交通大學學報(醫學版),2018,39(1):78-83. [2]張爽爽,夏慶民,鄭榮壽,等.中國2010年卵巢癌發病與死亡分析[J].中國腫瘤,2016,25(3):169-173. [3]陳燕,林鶯鶯,鄭瑜宏,等.血清HE4、CA125和ROMA指數評估卵巢癌風險性的初步評價[J].中國免疫學雜志,2013,29(2):168-174. [4]張碧蓮.HE4和CA125的聯合檢測對卵巢癌的早期診斷與鑒別診斷的臨床意義[J].實驗與檢驗醫學,2015,33(5):659-661. [5]馬美英,張廣禮,李莉.HE4、CA125及ROMA指數在早期漿液性卵巢癌診斷中的價值[J].腫瘤學雜志,2018,24(1):74-76.

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更新日期/Last Update: 2020-02-15
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